Preferential formation and decreased removal of cisplatin–DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA
OA Olivero, PK Chang, DM Lopez-Larraza… - … /Genetic Toxicology and …, 1997 - Elsevier
Levels of DNA adducts in Chinese hamster ovary (CHO) cells exposed to cis-
diamminedichloroplatinum (II)(cisplatin) for 24 h, have been shown to be 4-to 6-fold higher
in mitochondrial (mt) DNA as compared to nuclear (n) DNA (Olivero et al., Mutation Res.,
346 (1995) 221). The aim of the present study was to understand if the preferential cisplatin
binding in mtDNA is partially caused by lack of adduct removal in the mitochondria. Chinese
hamster ovary cells were exposed for 6 h to 50 μM cisplatin, followed by incubation for 24 …
diamminedichloroplatinum (II)(cisplatin) for 24 h, have been shown to be 4-to 6-fold higher
in mitochondrial (mt) DNA as compared to nuclear (n) DNA (Olivero et al., Mutation Res.,
346 (1995) 221). The aim of the present study was to understand if the preferential cisplatin
binding in mtDNA is partially caused by lack of adduct removal in the mitochondria. Chinese
hamster ovary cells were exposed for 6 h to 50 μM cisplatin, followed by incubation for 24 …
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